Original Contribution Lactase Persistence and Bitter Taste Response: Instrumental Variables and Mendelian Randomization in Epidemiologic Studies of Dietary Factors and Cancer Risk
نویسندگان
چکیده
1 Centre for Cancer Epidemiology and Prevention (CPO Piemonte), Turin, Italy. 2 Institute for Scientific Interchange (ISI) Foundation, Turin, Italy. 3 MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Bristol, United Kingdom. 4 Epidemiology Unit, National Cancer Institute, Milan, Italy. 5 Molecular and Nutritional Epidemiology Unit, Centre for the Study of Cancer Prevention (CSPO), Scientific Institute of Tuscany, Florence, Italy. 6 Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy. 7 Ragusa Cancer Registry, Ragusa, Italy. 8 Department of Epidemiology and Public Health, Imperial College London, London, United Kingdom.
منابع مشابه
Lactase persistence and bitter taste response: instrumental variables and mendelian randomization in epidemiologic studies of dietary factors and cancer risk.
Consumption of dairy products seems to increase the risk of cancer at several sites, while intake of cruciferous vegetables could have protective effects. However, these dietary intakes are subject to measurement error, and associations with cancer could be due to confounders. Mendelian randomization has been suggested as a way to overcome confounding by exploiting the random allocation of alle...
متن کاملMendelian randomization: how it can--and cannot--help confirm causal relations between nutrition and cancer.
Observational epidemiologic studies of nutrition and cancer have faced formidable methodologic obstacles, including dietary measurement error and confounding. We consider whether Mendelian randomization can help surmount these obstacles. The Mendelian randomization strategy, building on both the accuracy of genotyping and the random assortment of alleles at meiosis, involves searching for an as...
متن کاملDairy consumption, systolic blood pressure, and risk of hypertension: Mendelian randomization study
ObjeCtive To examine whether previous observed inverse associations of dairy intake with systolic blood pressure and risk of hypertension were causal. Design Mendelian randomization study using the single nucleotide polymorphism rs4988235 related to lactase persistence as an instrumental variable. setting CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium. PartiCiP...
متن کاملDairy consumption, systolic blood pressure, and risk of hypertension: Mendelian randomization study.
Objective To examine whether previous observed inverse associations of dairy intake with systolic blood pressure and risk of hypertension were causal.Design Mendelian randomization study using the single nucleotide polymorphism rs4988235 related to lactase persistence as an instrumental variable.Setting CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium.Participant...
متن کاملEmerging Themes in Epidemiology Analytic perspective Can we apply the Mendelian randomization methodology without considering epigenetic effects?
Introduction: Instrumental variable (IV) methods have been used in econometrics for several decades now, but have only recently been introduced into the epidemiologic research frameworks. Similarly, Mendelian randomization studies, which use the IV methodology for analysis and inference in epidemiology, were introduced into the epidemiologist's toolbox only in the last decade. Analysis: Mendeli...
متن کامل